The design of behavioural phenotyping experiments is determined by the animal model, the expected behavioural impairments and the associated hypothesis. While some studies are mainly explorative and search for new and unknown behavioural abnormalities, others focus on the identification of symptoms related to a human disorder or try to assess the functionality related to a specific brain area.

Specific evaluation of animal behaviours related to human symptoms of neuropsychiatric disorders

The Berlin Mouse Clinic has extensive experience in associating behavioural phenotypes of animals with manifestations of human neuropsychiatric disorders. We therefore propose specific batteries of tests that can be used to identify animal behaviours similar to those observed in humans.

Associated approaches to the development of animal models of human psychiatric and neurological disorders:

  • Search for endophenotypes
  • Dimensional approach of behaviour expression
  • Importance of differential diagnostics because of the high comorbidity of symptoms